PWWP3A

The PWWP domain mediates the interaction with nucleosomes.

Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.

Belongs to the PWWP3A family.

• Nucleus
• Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.

EXPAND1, MUM1, PWWP3A, PWWP domain-containing DNA repair factor 3A, Mutated melanoma-associated antigen 1, PWWP domain-containing protein MUM1, Protein expandere, MUM-1

• entrezGene:84939
• omim:601900
• swissprot:Q2TAK8

Proteins

Oncology

78636Da