PWWP3A
Domain
The PWWP domain mediates the interaction with nucleosomes.
Function
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
Sequence Similarities
Belongs to the PWWP3A family.
Cellular localization
- Nucleus
- Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.
Alternative names
EXPAND1, MUM1, PWWP3A, PWWP domain-containing DNA repair factor 3A, Mutated melanoma-associated antigen 1, PWWP domain-containing protein MUM1, Protein expandere, MUM-1