PYDC1
Function
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Post-translational modifications
Phosphorylated.
Tissue Specificity
Predominantly expressed in monocytes, macrophages and granulocytes.
Cellular localization
- Cytoplasm
- Recruited to specks formed by PYCARD within the cytoplasm.
Alternative names
ASC2, ASCI, POP1, PYC1, PYDC1, Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, cellular POP1, cPOP1