PZP

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

Plasma. Prominent constituent of late-pregnancy sera.

• Secreted

CPAMD6, PZP, Pregnancy zone protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

• entrezGene:5858
• omim:176420
• swissprot:P20742

Proteins

163863Da