Quiescin Q6

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560).

N-glycosylated (PubMed:17331072, PubMed:29757379). O-glycosylated on Thr and Ser residues (PubMed:29757379).

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.

• Isoform 1
• Golgi apparatus membrane
• Single-pass membrane protein
• Secreted
• A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor.
• Isoform 2
• Secreted
• Found in the extracellular medium of quiescent cells but is not found in proliferating cells.

QSCN6, UNQ2520/PRO6013, QSOX1, Sulfhydryl oxidase 1, hQSOX, Quiescin Q6

• entrezGene:5768
• omim:603120
• swissprot:O00391

Proteins

Oncology

82578Da