QTRT2
Function
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Sequence Similarities
Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
Cellular localization
- Cytoplasm
- Mitochondrion outer membrane
- Peripheral membrane protein
- Cytoplasmic side
- May associate with the mitochondrion outer membrane.
Alternative names
QTRTD1, QTRT2, Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase domain-containing protein 1