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RAB10

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (PubMed:17403373, PubMed:22908308, PubMed:27354378). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (PubMed:20643919). Also plays a specific role in asymmetric protein transport to the plasma membrane (By similarity). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (By similarity). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (By similarity). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (By similarity). When phosphorylated by LRRK2 on Thr-73, it binds RILPL1 and inhibits ciliogenesis (By similarity). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (By similarity). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220).

Post-translational modifications

Phosphorylation of Thr-73 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2 (By similarity). Phosphorylation of Thr-73 by LRRK2 is stimulated by RAB29 and RAB32 (By similarity). Phosphorylation by LRRK2 is required for localization to stressed lysosomes (PubMed:30209220).

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Tissue specificity

Expressed in the brain, specifically neurons (at protein level).

Cellular localization

  • Cytoplasmic vesicle membrane
  • Lipid-anchor
  • Cytoplasmic side
  • Golgi apparatus
  • trans-Golgi network membrane
  • Endosome membrane
  • Recycling endosome membrane
  • Cytoplasmic vesicle
  • Phagosome membrane
  • Cytoplasm
  • Cytoskeleton
  • Cilium basal body
  • Endoplasmic reticulum membrane
  • Cytoplasm
  • Perinuclear region
  • Lysosome
  • Associates with SLC2A4/GLUT4 storage vesicles (PubMed:27354378). Localizes to the base of the cilium when phosphorylated by LRRK2 on Thr-73 (PubMed:20576682, PubMed:27354378). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth (By similarity). Localizes to enlarged lysosomes through LRRK2 phosphorylation (PubMed:30209220).

Alternative names

  • Ras-related protein Rab-10
  • Rab10

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

22541Da

We found 1 product in 1 category

Proteins & Peptides

Target

Species of origin

Nature

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