RAB10

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220).

(Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole.

Ubiquitinated upon Legionella pneumophila infection. Ubiquitination does not lead to proteasomal degradation.

Phosphorylation of Thr-73 in the switch II region by LRRK2 prevents the association of dRAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2 (PubMed:26824392). Phosphorylation of Thr-73 by LRRK2 is stimulated by RAB29 and RAB32 (PubMed:38127736). Phosphorylation by LRRK2 is required for localization to stressed lysosomes (PubMed:30209220).

Belongs to the small GTPase superfamily. Rab family.

Expressed in the hippocampus (PubMed:29562525). Expressed in neutrophils (at protein level) (PubMed:29127255). Expressed in the testis (at protein level) (PubMed:28067790).

• Cytoplasmic vesicle membrane
• Lipid-anchor
• Cytoplasmic side
• Golgi apparatus membrane
• Golgi apparatus
• trans-Golgi network membrane
• Endosome membrane
• Recycling endosome membrane
• Cytoplasmic vesicle
• Phagosome membrane
• Cytoplasm
• Cytoskeleton
• Cilium basal body
• Endoplasmic reticulum membrane
• Cytoplasm
• Perinuclear region
• Lysosome
• Associates with SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Localizes to the base of the cilium when phosphorylated by LRRK2 on Thr-73 (PubMed:20576682, PubMed:30398148). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth (PubMed:23263280). Colocalizes with MICAL1, GRAF1/ARHGAP26 and GRAF2/ARHGAP10 on endosomal tubules (PubMed:32344433). Localizes to enlarged lysosomes through LRRK2 phosphorylation (PubMed:30209220).

Ras-related protein Rab-10, RAB10

• entrezGene:10890
• omim:612672
• swissprot:P61026

Proteins

Neuroscience

22541Da