RAB11FIP2
Function
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.
Post-translational modifications
Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.
Cellular localization
- Cell projection
- Phagocytic cup
- Cell membrane
- Peripheral membrane protein
- Recycling endosome membrane
- Peripheral membrane protein
- Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
Alternative names
KIAA0941, RAB11FIP2, Rab11 family-interacting protein 2, Rab11-FIP2, NRip11