RAB11FIP5
Domain
Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+).
Function
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Post-translational modifications
Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent.
Tissue Specificity
Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.
Cellular localization
- Cytoplasm
- Recycling endosome membrane
- Peripheral membrane protein
- Early endosome membrane
- Peripheral membrane protein
- Golgi apparatus membrane
- Peripheral membrane protein
- Cytoplasmic vesicle
- Secretory vesicle membrane
- Peripheral membrane protein
- Mitochondrion membrane
- Peripheral membrane protein
Alternative names
GAF1, KIAA0857, RIP11, RAB11FIP5, Rab11 family-interacting protein 5, Rab11-FIP5, Gamma-SNAP-associated factor 1, Phosphoprotein pp75, Rab11-interacting protein Rip11, Gaf-1