RAB12 phospho S106
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).
Post-translational modifications
Phosphorylation of Ser-106 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Cellular localization
- Recycling endosome membrane
- Lipid-anchor
- Cytoplasmic side
- Lysosome membrane
- Lipid-anchor
- Cytoplasmic side
- Golgi apparatus membrane
- Cytoplasmic vesicle
- Autophagosome
Alternative names
Ras-related protein Rab-12, RAB12