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RAB12 phospho S106

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).

Post-translational modifications

Phosphorylation of Ser-106 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Cellular localization

  • Recycling endosome membrane
  • Lipid-anchor
  • Cytoplasmic side
  • Lysosome membrane
  • Lipid-anchor
  • Cytoplasmic side
  • Golgi apparatus membrane
  • Cytoplasmic vesicle
  • Autophagosome

Alternative names

  • Ras-related protein Rab-12
  • RAB12

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

27248Da