RAB27B
Function
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Tissue Specificity
Expressed primarily in testis.
Cellular localization
- Membrane
- Lipid-anchor
- Late endosome
Alternative names
Ras-related protein Rab-27B, C25KG, RAB27B