RAB39A
Function
Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (PubMed:24349490). May be involved in multiple neurite formation (By similarity).
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Cytoplasmic vesicle
- Phagosome
- Cytoplasmic vesicle
- Phagosome membrane
- Lipid-anchor
- Cytoplasmic side
- Lysosome
- Recruited to phagosomes containing S.aureus or M.tuberculosis.
Alternative names
RAB39, RAB39A, Ras-related protein Rab-39A, Rab-39