RAB4A
Function
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420). Involved in protein transport (PubMed:29425100). Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
Post-translational modifications
Phosphorylated by CDK1 kinase during mitosis.
Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Cellular localization
- Membrane
- Peripheral membrane protein
- Cytoplasm
- Early endosome membrane
- Peripheral membrane protein
- Recycling endosome membrane
- Peripheral membrane protein
- Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.
Alternative names
RAB4, RAB4A, Ras-related protein Rab-4A