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Rab4

OverviewProducts

Function

Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420). Involved in protein transport (PubMed:29425100). Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).

Post-translational modifications

Phosphorylated by CDK1 kinase during mitosis.

Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Cellular localization

  • Membrane
  • Peripheral membrane protein
  • Cytoplasm
  • Early endosome membrane
  • Peripheral membrane protein
  • Recycling endosome membrane
  • Peripheral membrane protein
  • Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.

Alternative names

  • Ras-related protein Rab-4A
  • RAB4
  • RAB4A

Database links

Target type

Proteins

Molecular weight

24390Da