RAB4B
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (Probable). Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (PubMed:20534812). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
Post-translational modifications
Serotonylation of Gln-67 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Early endosome membrane
- Lipid-anchor
- Cytoplasmic side
Alternative names
RAB4, PP1596, RAB4B, Ras-related protein Rab-4B