RAB5C
Function
Protein transport. Probably involved in vesicular traffic.
Post-translational modifications
Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
(Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Early endosome membrane
- Lipid-anchor
- Melanosome
- Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Alternative names
RABL, RAB5C, Ras-related protein Rab-5C, L1880, RAB5L