RAB9A
Function
Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Endoplasmic reticulum membrane
- Golgi apparatus membrane
- Late endosome
- Cytoplasmic vesicle
- Phagosome membrane
- Lipid-anchor
- Cytoplasmic side
- Cytoplasmic vesicle
- Phagosome
- Cytoplasmic vesicle membrane
- Melanosome
- Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Alternative names
RAB9, RAB9A, Ras-related protein Rab-9A