RABAC1
Developmental stage
In fetal tissues, it is more abundant in kidney and lung.
Function
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.
Sequence Similarities
Belongs to the PRA1 family.
Tissue Specificity
Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cytoplasm
- Golgi apparatus
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle
- According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles.
Alternative names
PRA1, PRAF1, RABAC1, Prenylated Rab acceptor protein 1, PRA1 family protein 1