RABGAP1

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.

May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.

• Cytoplasm
• Cytosol
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome
• Predominantly cytosolic but also associated with the centrosome.

HSPC094, RABGAP1, Rab GTPase-activating protein 1, GAP and centrosome-associated protein, Rab6 GTPase-activating protein GAPCenA

• entrezGene:23637
• swissprot:Q9Y3P9

Proteins

Neuroscience

121737Da