RAET1E
Domain
MHC class I alpha-1 like and MHC class I alpha- like regions down-regulate the cell surface expression of KLRK1.
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Sequence Similarities
Belongs to the MHC class I family.
Tissue Specificity
Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Isoform 4
- Secreted
Alternative names
LETAL, N2DL4, ULBP4, UNQ1867/PRO4303, RAET1E, Retinoic acid early transcript 1E, Lymphocyte effector toxicity activation ligand, NKG2D ligand 4, RAE-1-like transcript 4, UL16-binding protein 4, N2DL-4, NKG2DL4