RAET1L
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Sequence Similarities
Belongs to the MHC class I family.
Tissue Specificity
Widely expressed (PubMed:11827464). Expressed in trachea (PubMed:19658097). Constitutively expressed in peripheral blood mononuclear cells, including B-cells and natural killer cells, as well as CD4+ and CD8+ T-cells and monocytes. Tends to be up-regulated in various lymphoid malignancies, including chronic lymphocytic leukemia (PubMed:28559451).
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Endoplasmic reticulum
- In CMV-infected fibroblasts, detected intracellularly.
Alternative names
ULBP6, RAET1L, UL16-binding protein 6, Retinoic acid early transcript 1L protein