RANGRF
Function
May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:21621375, PubMed:23420830).
Sequence Similarities
Belongs to the MOG1 family.
Tissue Specificity
Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375).
Cellular localization
- Nucleus
- Cytoplasm
- Perinuclear region
- Cytoplasm
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- May shuttle between the nucleus and cytoplasm.
Alternative names
MOG1, RANGNRF, HSPC165, HSPC236, MDS5, RANGRF, Ran guanine nucleotide release factor, RanGNRF, Ran-binding protein MOG1