RAP1B

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).

Belongs to the small GTPase superfamily. Ras family.

• Cell membrane
• Cytoplasm
• Cytosol
• Cell junction
• May shuttle between plasma membrane and cytosol (By similarity). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (By similarity).

Ras-related protein Rap-1b, GTP-binding protein smg p21B, Rap1b

• swissprot:Q62636

Proteins

Oncology

20798Da