RAPGEF5
Function
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.
Tissue Specificity
Widely expressed with highest levels in brain.
Cellular localization
- Nucleus
Alternative names
GFR, KIAA0277, MRGEF, RAPGEF5, Rap guanine nucleotide exchange factor 5, Guanine nucleotide exchange factor for Rap1, M-Ras-regulated Rap GEF, Related to Epac, MR-GEF, Repac