RAPH1

Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.

Belongs to the MRL family.

Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells.

• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cell projection
• Lamellipodium
• Cell projection
• Filopodium
• Cytoplasm
• Cytoskeleton
• Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.

ALS2CR18, ALS2CR9, KIAA1681, LPD, PREL2, RMO1, RAPH1, Ras-associated and pleckstrin homology domains-containing protein 1, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein, Lamellipodin, Proline-rich EVH1 ligand 2, Protein RMO1, PREL-2

• entrezGene:65059
• omim:609035
• swissprot:Q70E73

Proteins

Oncology

135256Da