RARG

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Expressed in aortic endothelial cells (at protein level).

• Nucleus
• Cytoplasm

NR1B3, RARG, Retinoic acid receptor gamma, RAR-gamma, Nuclear receptor subfamily 1 group B member 3

• entrezGene:5916
• omim:180190
• swissprot:P13631

Proteins

Oncology

49308Da