Ras-related and estrogen-regulated growth inhibitor
Function
Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
Sequence Similarities
Belongs to the small GTPase superfamily. Ras family.
Tissue Specificity
Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.
Cellular localization
- Cytoplasm
Alternative names
Ras-related and estrogen-regulated growth inhibitor, RERG