Ras-related protein R-Ras
Function
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).
Post-translational modifications
S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.
Sequence Similarities
Belongs to the small GTPase superfamily. Ras family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
Alternative names
Ras-related protein R-Ras, p23, RRAS