Ras-related protein Rab-27B

Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).

Belongs to the small GTPase superfamily. Rab family.

Expressed primarily in testis.

• Membrane
• Lipid-anchor
• Late endosome

Ras-related protein Rab-27B, C25KG, RAB27B

• entrezGene:5874
• omim:603869
• swissprot:O00194

Proteins

Neuroscience

24608Da