Ras-related protein Rab-32
Function
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736).
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Tissue Specificity
Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
Cellular localization
- Mitochondrion
- Mitochondrion outer membrane
- Lipid-anchor
- Cytoplasmic vesicle
- Phagosome
- Cytoplasmic vesicle
- Phagosome membrane
- Lipid-anchor
- Cytoplasmic side
- Melanosome
- Melanosome membrane
- Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
Alternative names
Ras-related protein Rab-32, RAB32