Skip to main content

Ras-related protein Rab-5A

Function

Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).

Post-translational modifications

Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.

(Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Cellular localization

  • Cell membrane
  • Lipid-anchor
  • Cytoplasmic side
  • Early endosome membrane
  • Lipid-anchor
  • Melanosome
  • Cytoplasmic vesicle
  • Cell projection
  • Ruffle
  • Membrane
  • Cytoplasm
  • Cytosol
  • Cytoplasmic vesicle
  • Phagosome membrane
  • Endosome membrane
  • Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable).

Alternative names

RAB5, RAB5A, Ras-related protein Rab-5A

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

23659Da

We found 11 products in 3 categories

Primary Antibodies

Proteins & Peptides

Target

Species of origin

Nature

Cell Lines & Lysates

Target

Cell type

Species or organism