Ras-related protein Rap-2b
Domain
The effector domain mediates the interaction with RUNDC3A.
Function
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
Post-translational modifications
Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK.
Sequence Similarities
Belongs to the small GTPase superfamily. Ras family.
Tissue Specificity
Expressed in red blood cells (at protein level).
Cellular localization
- Recycling endosome membrane
- Lipid-anchor
- Cytoplasmic side
- Associated with red blood cells-released vesicles.
Alternative names
Ras-related protein Rap-2b, RAP2B