RASA4
Domain
The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
Function
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Tissue Specificity
Widely expressed.
Cellular localization
- Cytoplasm
- Cytosol
- Cell membrane
- Peripheral membrane protein
- Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
Alternative names
CAPRI, GAPL, KIAA0538, RASA4, Ras GTPase-activating protein 4, Calcium-promoted Ras inactivator, Ras p21 protein activator 4, RasGAP-activating-like protein 2