RASEF
Function
Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157).
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Tissue Specificity
Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
Cellular localization
- Cytoplasm
- Perinuclear region
Alternative names
RAB45, RASEF, Ras and EF-hand domain-containing protein, Ras-related protein Rab-45