RASN
Function
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Post-translational modifications
Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.
Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.
Sequence Similarities
Belongs to the small GTPase superfamily. Ras family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Golgi apparatus membrane
- Lipid-anchor
- Shuttles between the plasma membrane and the Golgi apparatus.
Alternative names
GTPase NRas, Transforming protein N-Ras, Nras