RASSF2
Function
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.
Post-translational modifications
Phosphorylated by STK3/MST2 and STK4/MST1.
Tissue Specificity
Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.
Cellular localization
- Nucleus
- Cytoplasm
- Chromosome
- Centromere
- Kinetochore
- Translocates to the cytoplasm in the presence of STK3/MST2 and STK4/MST1.
Alternative names
CENP-34, KIAA0168, RASSF2, Ras association domain-containing protein 2