RASSF7
Function
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Post-translational modifications
Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Colocalizes with gamma-tubulin.
Alternative names
C11orf13, HRC1, RASSF7, Ras association domain-containing protein 7, HRAS1-related cluster protein 1