RBBP4

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Sequence similarities

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.

Cellular localization

• Nucleus
• Localizes to chromatin as part of the PRC2 complex.

Alternative names

• Histone-binding protein RBBP4
• Chromatin assembly factor 1 subunit C
• Chromatin assembly factor I p48 subunit
• Nucleosome-remodeling factor subunit RBAP48
• Retinoblastoma-binding protein 4
• Retinoblastoma-binding protein p48
• CAF-1 subunit C
• CAF-I 48 kDa subunit
• CAF-I p48
• RBBP-4
• RBBP4
• RBAP48

Database links

• entrezGene:121536
• entrezGene:23512
• entrezGene:5928
• entrezGene:8726
• entrezGene:2145
• entrezGene:2146
• omim:601573
• omim:602923
• omim:601674
• omim:605984
• omim:606245
• swissprot:Q09028
• swissprot:Q92800
• swissprot:Q6ZN18
• swissprot:Q15910
• swissprot:Q15022
• swissprot:O75530

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

47656Da