RBBP4

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Sequence Similarities

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.

Tissue Specificity

Expressed in neuroblastoma cells.

Cellular localization

• Nucleus
• Chromosome
• Telomere
• Localizes to chromatin as part of the PRC2 complex.

Alternative names

RBAP48, RBBP4, Histone-binding protein RBBP4, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling factor subunit RBAP48, Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, CAF-1 subunit C, CAF-I 48 kDa subunit, CAF-I p48, RBBP-4

Database links

swissprot:Q09028 omim:601573 omim:602923 omim:601674 entrezGene:121536 entrezGene:23512 entrezGene:5928 entrezGene:8726 entrezGene:2145 entrezGene:2146 swissprot:Q92800 swissprot:Q6ZN18 swissprot:Q15910 swissprot:Q15022 swissprot:O75530 omim:605984 omim:606245