RCAN1
Function
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).
Post-translational modifications
Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.
Sequence Similarities
Belongs to the RCAN family.
Tissue Specificity
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
Alternative names
ADAPT78, CSP1, DSC1, DSCR1, RCAN1, Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, Regulator of calcineurin 1, MCIP1