Rcn3
Developmental stage
During lung development the expression is detected from 15.5 dpc to P1 with a maximum at 17.5 dpc which corresponds to the stage of development of alveolar saccules.
Function
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:26252542). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (PubMed:26252542). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (PubMed:26252542). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity).
Post-translational modifications
Degraded by PCSK6 and other endoproteases including FURIN and PCSK5.
N-glycosylated.
Sequence Similarities
Belongs to the CREC family.
Tissue Specificity
Highly expressed in lung and heart. Also detected in liver, spleen, kidney, skeletal muscle, intestine, stomach, and brain.
Cellular localization
- Endoplasmic reticulum lumen
Alternative names
D7Ertd671e, Rcn3, Reticulocalbin-3