RCN3
Function
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634).
Post-translational modifications
Degraded by PCSK6 and other endoproteases including FURIN and PCSK5.
N-glycosylated.
Sequence Similarities
Belongs to the CREC family.
Tissue Specificity
Widely expressed.
Cellular localization
- Endoplasmic reticulum lumen
Alternative names
UNQ239/PRO272, RCN3, Reticulocalbin-3, EF-hand calcium-binding protein RLP49