RCOR1
Domain
The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A.
Function
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Post-translational modifications
Phosphorylated by HSV-1 protein kinases in case of infection.
Sequence Similarities
Belongs to the CoREST family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Nucleus
- Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
Alternative names
KIAA0071, RCOR, RCOR1, REST corepressor 1, Protein CoREST