Retinol dehydrogenase 16

The C-terminal region plays a crucial role in controlling the activity of RDH16 and its required for endoplasmic reticulum (ER) retention.

Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:29541409, PubMed:9677409).

Cofactor metabolism; retinol metabolism.

Not N-glycosylated.

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Highly expressed in adult liver (at protein level) (PubMed:9677409). Detected in endometrium, liver and foreskin (PubMed:10329026, PubMed:11967490). Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers (PubMed:10329026). Detected in fetal liver and lung.

• Microsome membrane
• Endoplasmic reticulum membrane
• Single-pass membrane protein

RODH4, SDR9C8, RDH16, Retinol dehydrogenase 16, Human epidermal retinol dehydrogenase, Microsomal NAD(+)-dependent retinol dehydrogenase 4, Short chain dehydrogenase/reductase family 9C member 8, Sterol/retinol dehydrogenase, hRDH-E, RoDH-4

• entrezGene:8608
• swissprot:O75452

Proteins

Immuno-oncology

35673Da