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Retinol dehydrogenase 16

OverviewProducts

Domain

The C-terminal region plays a crucial role in controlling the activity of RDH16 and its required for endoplasmic reticulum (ER) retention.

Function

Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409).

Pathway

Cofactor metabolism; retinol metabolism.

Post-translational modifications

Not N-glycosylated.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Tissue specificity

Highly expressed in adult liver (at protein level) (PubMed:9677409). Detected in endometrium, liver and foreskin (PubMed:10329026, PubMed:11967490). Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers (PubMed:10329026). Detected in fetal liver and lung.

Cellular localization

  • Microsome membrane
  • Endoplasmic reticulum membrane
  • Single-pass membrane protein

Alternative names

  • Retinol dehydrogenase 16
  • Human epidermal retinol dehydrogenase
  • Microsomal NAD(+)-dependent retinol dehydrogenase 4
  • Short chain dehydrogenase/reductase family 9C member 8
  • Sterol/retinol dehydrogenase
  • hRDH-E
  • RoDH-4
  • RODH4
  • RDH16
  • SDR9C8

Database links

Target type

Proteins

Molecular weight

35673Da