recA
Function
Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352).
Mutations in this gene were selected in directed evolution experiments for resistance to intense ionizing radiation (3000 Gy).
Sequence Similarities
Belongs to the RecA family.
Cellular localization
- Cytoplasm
Alternative names
lexB, recH, rnmB, tif, umuB, zab, b2699, JW2669, recA, Protein RecA, Recombinase A