Receptor activity-modifying protein 3
Function
Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1) (PubMed:23674134, PubMed:9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed:23674134, PubMed:9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed:35324283).
Sequence Similarities
Belongs to the RAMP family.
Tissue Specificity
Strongly expressed in lung, breast, immune system and fetal tissues.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Membrane
- Single-pass type I membrane protein
- Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
Alternative names
Receptor activity-modifying protein 3, Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3, RAMP3