REEP4
Function
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Sequence Similarities
Belongs to the DP1 family.
Tissue Specificity
Expressed in circumvallate papillae and testis.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
C8orf20, PP432, REEP4, Receptor expression-enhancing protein 4