REG1A

Developmental stage

High expression levels in fetal and infant brains; much lower in adult brains.

Function

Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

Post-translational modifications

The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine.

Tissue Specificity

In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients.

Cellular localization

• Secreted

Alternative names

PSPS, PSPS1, REG, REG1A, Lithostathine-1-alpha, Islet cells regeneration factor, Islet of Langerhans regenerating protein, Pancreatic stone protein, Pancreatic thread protein, Regenerating islet-derived protein 1-alpha, Regenerating protein I alpha, ICRF, PSP, PTP, REG-1-alpha

Database links

swissprot:P05451 entrezGene:5968 entrezGene:5967 swissprot:P48304 omim:167771 omim:167770