RESF1
Function
Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.
Cellular localization
- Nucleus
- Localizes around gamma-tubulin during M phase.
Alternative names
C12orf35, KIAA1551, RESF1, Retroelement silencing factor 1