RETN
GeneName
RETN
Summary
RETN, also known as resistin or ADSF, is an 11 kDa adipokine primarily secreted by adipocytes. It is found in various extracellular compartments, including the extracellular region and exosomes. RETN plays a role in fat cell differentiation and is involved in the regulation of feeding behaviour and insulin response. Additionally, it has been implicated in the positive regulation of progesterone secretion and synaptic transmission, indicating its multifaceted role in metabolic and neuroendocrine pathways.
Importance
RETN is relevant to: - Obesity and metabolic syndrome due to its role in insulin resistance and inflammation - Neurobiology, as it influences synaptic transmission and may affect mood and cognition - Reproductive health through its regulation of progesterone secretion - Potential therapeutic target for conditions related to energy homeostasis and metabolic disorders
Top Products
For researchers investigating RETN, we recommend two primary antibodies that cater to different experimental needs. The first is the well-regarded polyclonal antibody, Anti-Resistin antibody (ab216840), which has been cited in the literature and is specifically validated for immunohistochemistry (IHC). This makes it an excellent choice for those looking to study the expression of resistin in tissue samples. Additionally, we offer the recombinant monoclonal antibody, Anti-Resistin antibody [EPR23388-272] (ab272730). This antibody is suitable for western blotting (WB) and immunoprecipitation (IP), providing researchers with the reliability and consistency that comes with recombinant products. Together, these antibodies provide a comprehensive toolkit for studying RETN in various contexts. The Recombinant mouse Resistin protein (Active) ELISA Kit (ab269231) is an excellent option for researchers looking to measure Resistin levels in their samples.
Abcam Product Citation Summary
The data indicates that the RETN gene is being studied in the context of periodontitis, specifically using immunohistochemistry in rat maxillary molars. This suggests a focus on the role of RETN in periodontal disease mechanisms.
Abcam Product Citation Table
Function
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728).
Sequence Similarities
Belongs to the resistin/FIZZ family.
Tissue Specificity
Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at lower levels in lung, but not detected in other tissues (PubMed:15064728). Isoform 2 is detected in adipose tissue, bone marrow, brain, lung, peripheral blood, placenta and thymus (PubMed:15248836).
Cellular localization
- Secreted
Alternative names
FIZZ3, HXCP1, RSTN, UNQ407/PRO1199, RETN, Resistin, Adipose tissue-specific secretory factor, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3, ADSF