RETREG3
Domain
The LIR motif interacts with ATG8 family proteins.
Function
Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720).
Sequence Similarities
Belongs to the RETREG family.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Localizes preferentially to endoplasmic reticulum tubules and sheet edges.
Alternative names
FAM134C, RETREG3, Reticulophagy regulator 3